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Thomas's avatar

While I applaud your post here, there are clearly caveats that you might consider adding. For instance, my post-menopausal wife, who has among the healthiest lifestyles, nutritional choices and yes, even great brain and immune health of anyone I know, just was diagnosed with breast cancer, specifically an estrogen-positive cancer, meaning that her cancer is fed by, and may even be said to be caused by increased levels of estrogen in the body. In fact, many women in this category are given estrogen-REDUCING medications to lessen their cancer recurrence risk, if they survive the original cancer. You would do a great disservice to women who are in this category by giving them the impression that an estrogen-boosting medication can add longevity to their lives. Reader beware, and someone needs to run the numbers on things like the propensity of estrogen to SHORTEN lives in certain populations, vs the thesis of increasing lifespan.

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Paul von Zielbauer's avatar

Thomas, thank you for your note. Wishing your wife and you strength and return to full health as soon as possible.

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Dominic Gill's avatar

Interesting. Particularly the notion that ibuprofen could be categorized as a supplement. I wonder if there’s been any studies on benefits of this long term vs deleterious effect on the stomach, another organ that has a finite operating limit affected by stressors such as this. Ibuprofen is one of a collection of NSAIDs, perhaps one of the milder ones hence maybe the less risky inclusion in the category of ‘supplements’….but still curious.

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Paul von Zielbauer's avatar

Interesting question(s), all. For the uninitiated, NSAIDs — non-steroid anti-inflammatory drugs — stop your body from producing certain chemicals that cause inflammation. NSAIDs work like corticosteroids without steroid side effects.

The correlation of longevity and youthful organ age with these "supplements" including ibuprofin, vitamin C and multivitamins is indeed interesting. Maybe it's only a correlation (eg, people who are more athletic may tend to take more ibuprofin, esp as they age, and may be more health conscious and, thus, take more vitamins). And/or these "supplements" may serve as critical reducers of disease-helping inflammation, and serve to inhibit dying early. For the athletes among us, this is a question I'll be examining more deeply in 2025!

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